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Discovery of Xl01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood-Brain Barrier Penetrant Protac Degrader of Leucine-Rich Repeat Kinase 2

AuthID
P-00X-59E

Author(s)

Liu, XG

Kalogeropulou, AF

Domingos, S

Makukhin, N

Nirujogi, RS

Singh, F

Shpiro, N

Saalfrank, A

Sammler, E

Ganley, IG

Moreira, R

Alessi, DR

Ciulli, A

Document Type

Article in Press

Year published

2022

Published

in JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN: 0002-7863

Volume: 144, Issue: 37, Pages: 16930-16952 (23)

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Publication Identifiers

DOI: 10.1021/jacs.2c05499

Pubmed: 36007011

SCOPUS: 2-s2.0-85137398154

Wos: WOS:000848756900001

Source Identifiers

ISSN: 0002-7863

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Discovery of Xl01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood-Brain Barrier Penetrant Protac Degrader of Leucine-Rich Repeat Kinase 2

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Discovery of Xl01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood-Brain Barrier Penetrant Protac Degrader of Leucine-Rich Repeat Kinase 2

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