1
TITLE: The discovery of aryl-2-nitroethyl triamino pyrimidines as <i>anti-Trypanosoma brucei</i> agents  Full Text
AUTHORS: Linciano, Pasquale; Pozzi, Cecilia; Tassone, Giusy; Landi, Giacomo; Mangani, Stefano; Santucci, Matteo; Luciani, Rosaria; Ferrari, Stefania; Santarem, Nuno; Tagliazucchi, Lorenzo; Cordeiro da Silva, Anabela; Tonelli, Michele; Tondi, Donatella; Bertarini, Laura; Gul, Sheraz; Witt, Gesa; Moraes, Carolina B.; Costantino, Luca; Costi, Maria Paola;
PUBLISHED: 2024, SOURCE: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, VOLUME: 264
INDEXED IN: Scopus WOS
2
TITLE: Identification of Innovative Folate Inhibitors Leveraging the Amino Dihydrotriazine Motif from Cycloguanil for Their Potential as Anti-Trypanosoma brucei Agents
AUTHORS: Francesconi, Valeria; Rizzo, Marco; Pozzi, Cecilia; Tagliazucchi, Lorenzo; Simo, Claude U. Konchie; Saporito, Giulia; Landi, Giacomo; Mangani, Stefano; Carbone, Anna; Schenone, Silvia; Santarem, Nuno; Tavares, Joana; Cordeiro da Silva, Anabela; Costi, Maria Paola; Tonelli, Michele;
PUBLISHED: 2024, SOURCE: ACS INFECTIOUS DISEASES
INDEXED IN: Scopus WOS
3
TITLE: Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1  Full Text
AUTHORS: Pöhner, I; Quotadamo, A; Panecka Hofman, J; Luciani, R; Santucci, M; Linciano, P; Landi, G; Di Pisa, F; Dello Iacono, L; Pozzi, C; Mangani, S; Gul, S; Witt, G; Ellinger, B; Kuzikov, M; Santarem, N; Cordeiro Da Silva, A ; Costi, MP; Venturelli, A; Wade, RC;
PUBLISHED: 2022, SOURCE: Journal of Medicinal Chemistry, VOLUME: 65, ISSUE: 13
INDEXED IN: Scopus CrossRef: 2
4
TITLE: Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1  Full Text
AUTHORS: Poehner, Ina; Quotadamo, Antonio; Panecka Hofman, Joanna; Luciani, Rosaria; Santucci, Matteo; Linciano, Pasquale; Landi, Giacomo; Di Pisa, Flavio; Dello Iacono, Lucia; Pozzi, Cecilia; Mangani, Stefano; Gul, Sheraz; Witt, Gesa; Ellinger, Bernhard; Kuzikov, Maria; Santarem, Nuno; Cordeiro da Silva, Anabela; Costi, Maria P.; Venturelli, Alberto; Wade, Rebecca C.;
PUBLISHED: 2022, SOURCE: JOURNAL OF MEDICINAL CHEMISTRY
INDEXED IN: WOS
5
TITLE: Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1  Full Text
AUTHORS: Poehner, Ina; Quotadamo, Antonio; Panecka Hofman, Joanna; Luciani, Rosaria; Santucci, Matteo; Linciano, Pasquale; Landi, Giacomo; Di Pisa, Flavio; Dello Iacono, Lucia; Pozzi, Cecilia; Mangani, Stefano; Gul, Sheraz; Witt, Gesa; Ellinger, Bernhard; Kuzikov, Maria; Santarem, Nuno; Cordeiro da Silva, Anabela; Costi, Maria P.; Venturelli, Alberto; Wade, Rebecca C.;
PUBLISHED: 2022, SOURCE: JOURNAL OF MEDICINAL CHEMISTRY, VOLUME: 65, ISSUE: 13
INDEXED IN: WOS
6
TITLE: Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth
AUTHORS: Costantino, Luca; Ferrari, Stefania; Santucci, Matteo; Salo Ahen, Outi M. H.; Carosati, Emanuele; Franchini, Silvia; Lauriola, Angela; Pozzi, Cecilia; Trande, Matteo; Gozzi, Gaia; Saxena, Puneet; Cannazza, Giuseppe; Losi, Lorena; Cardinale, Daniela; Venturelli, Alberto; Quotadamo, Antonio; Linciano, Pasquale; Tagliazucchi, Lorenzo; Moschella, Maria Gaetana; Guerrini, Remo; Pacifico, Salvatore; Luciani, Rosaria; Genovese, Filippo; Henrich, Stefan; Alboni, Silvia; Santarem, Nuno; da Silva Cordeiro, Anabela ; Giovannetti, Elisa; Peters, Godefridus J.; Pinton, Paolo; Rimessi, Alessandro; Cruciani, Gabriele; Stroud, Robert M.; Wade, Rebecca C.; Mangani, Stefano; Marverti, Gaetano; D'Arca, Domenico; Ponterini, Glauco; Costi, Maria Paola; ...More
PUBLISHED: 2022, SOURCE: ELIFE, VOLUME: 11
INDEXED IN: Scopus WOS CrossRef Unpaywall
7
TITLE: Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6  Full Text
AUTHORS: Vanden Eynde, JJ; Mangoni, AA; Rautio, J; Leprince, J; Azuma, YT; Garcia Sosa, AT; Hulme, C; Jampilek, J; Karaman, R; Li, W; Paula Gomes ; Hadjipavlou Litina, D; Capasso, R; Geronikaki, A; Cerchia, L; Sabatier, JM; Ragno, R; Tuccinardi, T; Trabocchi, A; Winum, JY; Luque, FJ; Prokai Tatrai, K; Spetea, M; Gutschow, M; Kosalec, I; Guillou, C; Vasconcelos, MH ; Kokotos, G; Rastelli, G; de Sousa, ME ; Manera, C; Gemma, S; Mangani, S; Siciliano, C; Galdiero, S; Liu, H; Scott, PJH; de los Rios, C; Agrofoglio, LA; Collina, S; Guedes, RC; Munoz Torrero, D; ...More
PUBLISHED: 2020, SOURCE: MOLECULES, VOLUME: 25, ISSUE: 1
INDEXED IN: Scopus WOS CrossRef: 2 Unpaywall
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TITLE: Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-7  Full Text
AUTHORS: Gutschow, M; Vanden Eynde, JJ; Jampilek, J; Kang, CB; Mangoni, AA; Fossa, P; Karaman, R; Trabocchi, A; Scott, PJH; Reynisson, J; Rapposelli, S; Galdiero, S; Winum, JY; Brullo, C; Prokai Tatrai, K; Sharma, AK; Schapira, M; Azuma, YT; Cerchia, L; Spetea, M; Torri, G; Collina, S; Geronikaki, A; Garcia Sosa, AT; Vasconcelos, MH ; Sousa, ME ; Kosalec, I; Tuccinardi, T; Duarte, IF; Salvador, JAR; Bertinaria, M; Pellecchia, M; Amato, J; Rastelli, G; Paula Gomes ; Guedes, RC; Sabatier, JM; Estevez Braun, A; Pagano, B; Mangani, S; Ragno, R; Kokotos, G; Brindisi, M; Gonzalez, FV; Borges, F ; Miloso, M; Rautio, J; Munoz Torrero, D; ...More
PUBLISHED: 2020, SOURCE: MOLECULES, VOLUME: 25, ISSUE: 13
INDEXED IN: Scopus WOS CrossRef: 5 Unpaywall
9
TITLE: Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform
AUTHORS: Carolina B Moraes; Gesa Witt; Maria Kuzikov; Bernhard Ellinper; Theodora Calogeropoulou; Kyriakos C Prousis; Stefano Mangani; Flavio Di Pisa; Giacomo Landi; Lucia Dello Lacono; Cecilia Pozzi; Lucio H Freitas Junior; Bruno dos Santos Pascoalino; Claudia P Bertolacini; Birte Behrens; Oliver Keminer; Jennifer Leu; Markus Wolf; Jeanette Reinshagen; Anabela Cordeiro da Silva ; Nuno Santarem; Alberto Venturelli; Stephen Wrigley; Deepa Karunakaran; Bethlehem Kebede; Ina Poehner; Wolfgang Mueller; Joanna Panecka Hofman; Rebecca C Wade; Martina Fenske; Joachim Clos; Jose M Maria Alunda; Maria J Jesus Corral; Elisa Uliassi; Maria Laura Bolognesi; Pasquale Linciano; Antonio Quotadamo; Stefania Ferrari; Matteo Santucci; Chiara Borsari; Maria Paola Costi; Sheraz Gul; ...More
PUBLISHED: 2019, SOURCE: SLAS DISCOVERY, VOLUME: 24, ISSUE: 3
INDEXED IN: Scopus WOS CrossRef: 2
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TITLE: Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections  Full Text
AUTHORS: Pasquale Linciano; Cecilia Pozzi; Lucia dello Iacono; Flavio di Pisa; Giacomo Landi; Alessio Bonucci; Sheraz Gul; Maria Kuzikov; Bernhard Ellinger; Gesa Witt; Nuno Santarem; Catarina Baptista; Caio Franco; Carolina B Moraes; Wolfgang Mueller; Ulrike Wittig; Rosaria Luciani; Antony Sesenna; Antonio Quotadamo; Stefania Ferrari; Ina Pohner; Anabela Cordeiro da Silva ; Stefano Mangani; Luca Costantino; Maria Paola Costi; ...More
PUBLISHED: 2019, SOURCE: JOURNAL OF MEDICINAL CHEMISTRY, VOLUME: 62, ISSUE: 8
INDEXED IN: Scopus WOS CrossRef
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