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TITLE: N-Acyl and N-sulfonyloxazolidine-2,4-diones are pseudo-irreversible inhibitors of serine proteases  Full Text
AUTHORS: Ana Bela Santana; Susana D Lucas ; Lidia M Goncalves; Henrique F Correia; Teresa A F Cardote; Rita C Guedes ; Jim Iley; Rui Moreira ;
PUBLISHED: 2012, SOURCE: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, VOLUME: 22, ISSUE: 12
INDEXED IN: Scopus WOS CrossRef
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TITLE: A carbamate-based approach to primaquine prodrugs: Antimalarial activity, chemical stability and enzymatic activation  Full Text
AUTHORS: Graca Mata; Virgilio E do Rosario; Jim Iley; Luis Constantino ; Rui Moreira ;
PUBLISHED: 2012, SOURCE: BIOORGANIC & MEDICINAL CHEMISTRY, VOLUME: 20, ISSUE: 2
INDEXED IN: Scopus WOS CrossRef
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TITLE: Basic hydrolysis of quinolinyl N,N-dimethylcarbamates: a two-step mechanism  Full Text
AUTHORS: Daniel Silva ; Fatima Norberto; Susana Santos ; Jim Iley;
PUBLISHED: 2011, SOURCE: JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, VOLUME: 24, ISSUE: 11
INDEXED IN: Scopus WOS CrossRef
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TITLE: 4-Oxo-beta-lactams (Azetidine-2,4-diones) Are Potent and Selective Inhibitors of Human Leukocyte Elastase  Full Text
AUTHORS: Jalmira Mulchande; Rudi Oliveira; Marta Carrasco; Luis Gouveia ; Rita C Guedes ; Jim Iley; Rui Moreira ;
PUBLISHED: 2010, SOURCE: JOURNAL OF MEDICINAL CHEMISTRY, VOLUME: 53, ISSUE: 1
INDEXED IN: Scopus WOS CrossRef
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TITLE: Reaction of naphthoquinones with substituted nitromethanes. Facile synthesis and antifungal activity of naphtho[2,3-d]isoxazole-4,9-diones  Full Text
AUTHORS: Maria M M Santos ; Natalia Faria; Jim Iley; Simon J Coles; Michael B Hursthouse; Luz L Martins ; Rui Moreira ;
PUBLISHED: 2010, SOURCE: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, VOLUME: 20, ISSUE: 1
INDEXED IN: Scopus WOS CrossRef
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TITLE: Towards an efficient prodrug of the alkylating metabolite monomethyltriazene: Synthesis and stability of N-acylamino acid derivatives of triazenes  Full Text
AUTHORS: Maria de Jesus Perry; Emilia Carvalho; Eduarda Rosa; Jim Iley;
PUBLISHED: 2009, SOURCE: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, VOLUME: 44, ISSUE: 3
INDEXED IN: Scopus WOS CrossRef
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TITLE: The 1,4-naphthoquinone scaffold in the design of cysteine protease inhibitors  Full Text
AUTHORS: Claudia Valente; Rul Moreira ; Rita C Guedes ; Jim Iley; Mohammed Jaffar; Kenneth T Douglas;
PUBLISHED: 2007, SOURCE: BIOORGANIC & MEDICINAL CHEMISTRY, VOLUME: 15, ISSUE: 15
INDEXED IN: Scopus WOS CrossRef
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TITLE: Aminocarbonyloxymethyl ester prodrugs of flufenamic acid and diclofenac: Suppressing the rearrangement pathway in aqueous media  Full Text
AUTHORS: Lina Ribeiro; Nuno Silva; Jim Iley; Jarkko Rautio; Tomi Jarvinen; Heder Mota Filipe ; Rui Moreira ; Eduarda Mendes;
PUBLISHED: 2007, SOURCE: ARCHIV DER PHARMAZIE, VOLUME: 340, ISSUE: 1
INDEXED IN: Scopus WOS CrossRef
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