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TITLE: Multistage Antiplasmodium Activity of Astemizole Analogues and Inhibition of Hemozoin Formation as a Contributor to Their Mode of Action
AUTHORS: Malkeet Kumar; John Okombo; Dickson Mambwe; Dale Taylor; Nina Lawrence; Janette Reader; Mariette van der Watt; Diana Fontinha; Margarida Sanches Vaz; Belinda C Bezuidenhout; Sonja B Lauterbach; Dale Liebenberg; Lyn Marie Birkholtz; Theresa L Coetzer; Miguel Prudencio ; Timothy J Egan; Sergio Wittlin; Kelly Chibale;
PUBLISHED: 2019, SOURCE: ACS INFECTIOUS DISEASES, VOLUME: 5, ISSUE: 2
INDEXED IN: Scopus WOS CrossRef: 1
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TITLE: Structure-Activity Relationship Studies and Plasmodium Life Cycle Profiling Identifies Pan-Active N-Aryl-3-trifluoromethyl Pyrido[1,2-a]benzimidazoles Which Are Efficacious in an in Vivo Mouse Model of Malaria  Full Text
AUTHORS: Godfrey Mayoka; Mathew Njoroge; John Okombo; Liezl Gibhard; Margarida Sanches Vaz; Diana Fontinha; Lyn Marie Birkholtz; Janette Reader; Mariette van der Watt; Theresa L Coetzer; Sonja Lauterbach; Alisje Churchyard; Belinda Bezuidenhout; Timothy J Egan; Clive Yeates; Sergio Wittlin; Miguel Prudencio ; Kelly Chibale;
PUBLISHED: 2019, SOURCE: JOURNAL OF MEDICINAL CHEMISTRY, VOLUME: 62, ISSUE: 2
INDEXED IN: Scopus WOS CrossRef
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TITLE: Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model  Full Text
AUTHORS: Kawaljit Singh; John Okombo; Christel Brunschwig; Ferdinand Ndubi; Linley Barnard; Chad Wilkinson; Peter M Njogu; Mathew Njoroge; Lizahn Laing; Marta Machado; Miguel Prudencio; Janette Reader; Mariette Botha; Sindisiwe Nondaba; Lyn Marie Birkholtz; Sonja Lauterbach; Alisje Churchyard; Theresa L Coetzer; Jeremy N Burrows; Clive Yeates; Paolo Denti; Lubbe Wiesner; Timothy J Egan; Sergio Wittlin; Kelly Chibale; ...More
PUBLISHED: 2017, SOURCE: JOURNAL OF MEDICINAL CHEMISTRY, VOLUME: 60, ISSUE: 4
INDEXED IN: Scopus WOS CrossRef: 12
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TITLE: Primaquine-pyrimidine hybrids: Synthesis and dual-stage antiplasmodial activity  Full Text
AUTHORS: Hardeep Kaur; Marta Machado; Carmen de Kock; Peter Smith; Kelly Chibale; Miguel Prudencio ; Kamaljit Singh;
PUBLISHED: 2015, SOURCE: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, VOLUME: 101
INDEXED IN: Scopus WOS CrossRef
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TITLE: Novel anti-Plasmodial hits identified by virtual screening of the ZINC database  Full Text
AUTHORS: Grace Mugumbate; Ana S Newton; Philip J Rosenthal; Jiri Gut; Rui Moreira ; Kelly Chibale; Rita C Guedes ;
PUBLISHED: 2013, SOURCE: JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, VOLUME: 27, ISSUE: 10
INDEXED IN: Scopus WOS CrossRef